Multicellular Tumor Spheroids Combined with Mass Spectrometric Histone Analysis to Evaluate Epigenetic Drugs

Multicellular tumor spheroids (MCTS) are valuable in vitro tumor models frequently used to evaluate the penetration and efficacy of therapeutics. In this study, we evaluated potential differences in epigenetic markers, i.e. histone post-translational modifications (PTMs), in the layers of the HCT116...

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Udgivet i:Anal Chem
Main Authors: Feist, Peter E., Sidoli, Simone, Liu, Xin, Schroll, Monica M., Rahmy, Sharif, Fujiwara, Rina, Garcia, Benjamin A., Hummon, Amanda B.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371507/
https://ncbi.nlm.nih.gov/pubmed/28194967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b03602
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