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SpxA1 and SpxA2 Act Coordinately To Fine-Tune Stress Responses and Virulence in Streptococcus pyogenes

SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood. Here, we show that the SpxA paralogs of the pathogen Stre...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Port, Gary C., Cusumano, Zachary T., Tumminello, Paul R., Caparon, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371413/
https://ncbi.nlm.nih.gov/pubmed/28351920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00288-17
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