Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells

Tetraarsenic hexoxide (As(4)O(6)) has been used in Korean folk medicines for the treatment of cancer, however its anti-cancer mechanisms remain obscured. Here, this study investigated the anti-cancer effect of As(4)O(6) on SW620 human colon cancer cells. As(4)O(6) has showed a dose-dependent inhibit...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Nagappan, Arulkumar, Lee, Won Sup, Yun, Jeong Won, Lu, Jing Nan, Chang, Seong-Hwan, Jeong, Jae-Hoon, Kim, Gon Sup, Jung, Jin-Myung, Hong, Soon Chan
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371332/
https://ncbi.nlm.nih.gov/pubmed/28355296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174591
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