Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

BACKGROUND: Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by conditions that increase lifespan. Mice are part...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Wang, Tina, Tsui, Brian, Kreisberg, Jason F., Robertson, Neil A., Gross, Andrew M., Yu, Michael Ku, Carter, Hannah, Brown-Borg, Holly M., Adams, Peter D., Ideker, Trey
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371228/
https://ncbi.nlm.nih.gov/pubmed/28351423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1186-2
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