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Analysis of Matched Tumor and Normal Profiles Reveals Common Transcriptional and Epigenetic Signals Shared across Cancer Types

To identify the transcriptional regulatory changes that are most widespread in solid tumors, we performed a pan-cancer analysis using over 600 pairs of tumors and adjacent normal tissues profiled in The Cancer Genome Atlas (TCGA). Frequency of upregulation was calculated across mRNA expression level...

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Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Gross, Andrew M., Kreisberg, Jason F., Ideker, Trey
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640835/
https://ncbi.nlm.nih.gov/pubmed/26555223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142618
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