Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many vertebrate cell types. It appears to act intracellularly, as incubation of isolated rat liver microsomes with thapsigargin induces a rapid, dose-dependent release of stored Ca2...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Thastrup, O, Cullen, P J, Drøbak, B K, Hanley, M R, Dawson, A P
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1990
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53710/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2138778/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.7.2466
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