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Nonsense Suppression as an Approach to Treat Lysosomal Storage Diseases
In-frame premature termination codons (PTCs) (also referred to as nonsense mutations) comprise ~10% of all disease-associated gene lesions. PTCs reduce gene expression in two ways. First, PTCs prematurely terminate translation of an mRNA, leading to the production of a truncated polypeptide that oft...
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| Publicado en: | Diseases |
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| Autor principal: | |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
MDPI
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5370586/ https://ncbi.nlm.nih.gov/pubmed/28367323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/diseases4040032 |
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