Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells

Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies. We tested the hypothesis that targeted aromatase inhibition in an aggressive brain cancer called glioblastoma (GBM) may represent a new treatme...

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Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Tivnan, Amanda, Heilinger, Tatjana, Ramsey, Joanne M, O’Connor, Gemma, Pokorny, Jenny L, Sarkaria, Jann N, Stringer, Brett W, Day, Bryan W, Boyd, Andrew W, Kim, Ella L, Lode, Holger N, Cryan, Sally-Ann, Prehn, Jochen H.M
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369988/
https://ncbi.nlm.nih.gov/pubmed/28178667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15073
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