GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF

The alternative reading frame protein (p14ARF/ARF) is a key determinant of cell fate, acting as a potent tumor suppressor through a p53/MDM2-dependent pathway or promoting apoptosis in a p53-independent manner. The ARF protein is mainly expressed in the nucleolus and sequestered by nucleophosmin (NP...

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Udgivet i:Oncotarget
Main Authors: Lee, Sun, Cho, Young-Eun, Kim, Sang-Hoon, Kim, Yong-Jun, Park, Jae-Hoon
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369963/
https://ncbi.nlm.nih.gov/pubmed/27323397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9957
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