The dual role of thiourea in the thiotrifluoromethylation of alkenes

Alkenes substituted with a thiourea undergo C–CF(3) followed by intramolecular C–S bond formation with the Togni reagent and trifluoroacetic acid (TFA) at room temperature; thiols and thioamides are not suitable S-sources for this reaction. This anti-addition process involves a CF(3) radical, and af...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Ricci, Paolo, Khotavivattana, Tanatorn, Pfeifer, Lukas, Médebielle, Maurice, Morphy, John Richard, Gouverneur, Véronique
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369526/
https://ncbi.nlm.nih.gov/pubmed/28451260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc02790c
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