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Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.

Envelope glycoprotein gp120 of human immunodeficiency virus type 1 (HIV-1) is known to inhibit T-cell function, but little is known about the mechanisms of this immunosuppression. Pretreatment of a CD4+ tetanus toxoid-specific T-cell clone with soluble gp120 was found to exert a dose-dependent inhib...

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Detalhes bibliográficos
Main Authors: Oyaizu, N, Chirmule, N, Kalyanaraman, V S, Hall, W W, Pahwa, R, Shuster, M, Pahwa, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC53690/
https://ncbi.nlm.nih.gov/pubmed/2315327
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