Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.

Envelope glycoprotein gp120 of human immunodeficiency virus type 1 (HIV-1) is known to inhibit T-cell function, but little is known about the mechanisms of this immunosuppression. Pretreatment of a CD4+ tetanus toxoid-specific T-cell clone with soluble gp120 was found to exert a dose-dependent inhib...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Oyaizu, N, Chirmule, N, Kalyanaraman, V S, Hall, W W, Pahwa, R, Shuster, M, Pahwa, S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53690/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2315327/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.6.2379
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