New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali

BACKGROUND: Encoded by the var gene family, highly variable Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) proteins mediate tissue-specific cytoadherence of infected erythrocytes, resulting in immune evasion and severe malaria disease. Sequencing and assembling the 40–60 var gene comp...

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Bibliografische gegevens
Gepubliceerd in:Genome Med
Hoofdauteurs: Dara, Antoine, Drábek, Elliott F., Travassos, Mark A., Moser, Kara A., Delcher, Arthur L., Su, Qi, Hostelley, Timothy, Coulibaly, Drissa, Daou, Modibo, Dembele, Ahmadou, Diarra, Issa, Kone, Abdoulaye K., Kouriba, Bourema, Laurens, Matthew B., Niangaly, Amadou, Traore, Karim, Tolo, Youssouf, Fraser, Claire M., Thera, Mahamadou A., Djimde, Abdoulaye A., Doumbo, Ogobara K., Plowe, Christopher V., Silva, Joana C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2017
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368897/
https://ncbi.nlm.nih.gov/pubmed/28351419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0422-4
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