Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications

S009-131, a coumarin-chalcone hybrid, had been shown to possess anti-proliferative and anti-tumour effect by triggering apoptosis. In this report, we investigated role of DNA damage signalling pathway in S009-131 induced cancer cell death. Here we show that S009-131 causes DNA damage by potential bi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ashraf, Raghib, Hamidullah, Hasanain, Mohammad, Pandey, Praveen, Maheshwari, Mayank, Singh, L. Ravithej, Siddiqui, M. Quadir, Konwar, Rituraj, Sashidhara, Koneni V., Sarkar, Jayanta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368660/
https://ncbi.nlm.nih.gov/pubmed/28349922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45287
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