Adoptive Transfer of mRNA-Transfected T Cells Redirected against Diabetogenic CD8 T Cells Can Prevent Diabetes

Chimeric major histocompatibility complex (MHC) molecules supplemented with T cell receptor (TCR) signaling motifs function as activation receptors and can redirect gene-modified T cells against pathogenic CD8 T cells. We have shown that β(2) microglobulin (β(2)m) operates as a universal signaling c...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Fishman, Sigal, Lewis, Mark D., Siew, L. Khai, De Leenheer, Evy, Kakabadse, Dimitri, Davies, Joanne, Ziv, Doron, Margalit, Alon, Karin, Nathan, Gross, Gideon, Wong, F. Susan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368593/
https://ncbi.nlm.nih.gov/pubmed/28109957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.12.007
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