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The Flipside of the Power of Engineered T Cells: Observed and Potential Toxicities of Genetically Modified T Cells as Therapy

Autologous T cells modified to recognize novel antigen targets are a novel form of therapy for cancer. We review the various potential forms of observed and hypothetical toxicities associated with genetically modified T cells. Despite the focus on toxicities in this review, re-directed T cells repre...

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Pubblicato in:Mol Ther
Autori principali: Bedoya, Felipe, Frigault, Matthew J., Maus, Marcela V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368422/
https://ncbi.nlm.nih.gov/pubmed/28153085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.11.011
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