Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies

CD47 is a ubiquitously expressed immune checkpoint receptor that is often upregulated in cancer. CD47 interacts with its counter-receptor SIRPα on macrophages and other myeloid cells to inhibit cancer cell phagocytosis and drive immune evasion. To overcome tolerability and “antigen sink” issues aris...

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Publicat a:Mol Ther
Autors principals: Dheilly, Elie, Moine, Valéry, Broyer, Lucile, Salgado-Pires, Susana, Johnson, Zoë, Papaioannou, Anne, Cons, Laura, Calloud, Sébastien, Majocchi, Stefano, Nelson, Robert, Rousseau, François, Ferlin, Walter, Kosco-Vilbois, Marie, Fischer, Nicolas, Masternak, Krzysztof
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368402/
https://ncbi.nlm.nih.gov/pubmed/28153099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.11.006
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