Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to q...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Fielding, Ceri A, Weekes, Michael P, Nobre, Luis V, Ruckova, Eva, Wilkie, Gavin S, Paulo, Joao A, Chang, Chiwen, Suárez, Nicolás M, Davies, James A, Antrobus, Robin, Stanton, Richard J, Aicheler, Rebecca J, Nichols, Hester, Vojtesek, Borek, Trowsdale, John, Davison, Andrew J, Gygi, Steven P, Tomasec, Peter, Lehner, Paul J, Wilkinson, Gavin W G
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367895/
https://ncbi.nlm.nih.gov/pubmed/28186488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22206
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