Knock-in of Cx46 partially rescues fiber defects in lenses lacking Cx50

PURPOSE: Connexins 46 (Cx46) and 50 (Cx50) support lens development and homeostasis. Knockout (KO) of Cx50, but not Cx46, causes defects in lens fiber organization, F-actin enrichment, gap junction (GJ) size, ball-and-socket (BS) maturation, and GJ-associated protein distributions. To further determ...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Mol Vis
Autores principales: Wang, Eddie, Geng, Andrew, Seo, Richard, Maniar, Ankur, Gong, Xiaohua
Formato: Artigo
Lenguaje:Inglês
Publicado: Molecular Vision 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367893/
https://ncbi.nlm.nih.gov/pubmed/28458505
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares