Dynamically Complex [6+4] and [4+2] Cycloadditions in the Biosynthesis of Spinosyn A

SpnF, an enzyme involved in the biosynthesis of spinosyn A, catalyzes a transannular Diels–Alder reaction. Quantum mechanical computations and dynamic simulations now show that this cycloaddition is not well described as either a concerted or stepwise process, and dynamical effects influence the ide...

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Bibliografiske detaljer
Udgivet i:	J Am Chem Soc
Main Authors:	Patel, Ashay, Chen, Zhuo, Yang, Zhongyue, Gutiérrez, Osvaldo, Liu, Hung-wen, Houk, K. N., Singleton, Daniel A.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2016
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5367884/ https://ncbi.nlm.nih.gov/pubmed/26909570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b00017
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Dynamically Complex [6+4] and [4+2] Cycloadditions in the Biosynthesis of Spinosyn A

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