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Epigenetic silencing of V(D)J recombination is a major determinant for selective differentiation of mucosal-associated invariant t cells from induced pluripotent stem cells

Mucosal-associated invariant T cells (MAITs) are innate-like T cells that play a pivotal role in the host defense against infectious diseases, and are also implicated in autoimmune diseases, metabolic diseases, and cancer. Recent studies have shown that induced pluripotent stem cells (iPSCs) derived...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Saito, Yutaka, Sugimoto, Chie, Mituyama, Toutai, Wakao, Hiroshi
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367832/
https://ncbi.nlm.nih.gov/pubmed/28346544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174699
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