Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease

It is widely accepted that amyloid β (Aβ) generated from amyloid precursor protein (APP) oligomerizes and fibrillizes to form neuritic plaques in Alzheimer’s disease (AD), yet little is known about the contribution of APP to intracellular signaling events preceding AD pathogenesis. The data presente...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eNeuro
Egile Nagusiak: Kirouac, Lisa, Rajic, Alexander J., Cribbs, David H., Padmanabhan, Jaya
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2017
Gaiak:
New Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367084/
https://ncbi.nlm.nih.gov/pubmed/28374012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0149-16.2017
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