Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy

Beclin 1 is a well-established core mammalian autophagy protein that is embryonically indispensable and has been presumed to suppress oncogenesis via an autophagy-mediated mechanism. Here, we show that Beclin 1 is a prenatal primary cytoplasmic protein but rapidly relocated into the nucleus during p...

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Pubblicato in:Sci Rep
Autori principali: Xu, Fei, Fang, Yixuan, Yan, Lili, Xu, Lan, Zhang, Suping, Cao, Yan, Xu, Li, Zhang, Xiaoying, Xie, Jialing, Jiang, Gaoyue, Ge, Chaorong, An, Ni, Zhou, Daohong, Yuan, Na, Wang, Jianrong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366945/
https://ncbi.nlm.nih.gov/pubmed/28345663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45385
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