Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion

Prolyl hydroxylase enzymes (PHDs) sense cellular oxygen upstream of hypoxia-inducible factor (HIF) signaling, leading to HIF degradation in normoxic conditions. In this study, we demonstrate that adipose PHD2 inhibition plays a key role in the suppression of adipocyte lipolysis. Adipose Phd2 gene ab...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Michailidou, Zoi, Morton, Nicholas M., Moreno Navarrete, José Maria, West, Christopher C., Stewart, Kenneth J., Fernández-Real, José Manuel, Schofield, Christopher J., Seckl, Jonathan R., Ratcliffe, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366882/
https://ncbi.nlm.nih.gov/pubmed/25377876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0233
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