Characterization of the specific interaction between the DNA aptamer sgc8c and protein tyrosine kinase-7 receptors at the surface of T-cells by biosensing AFM

We studied the interaction of the specific DNA aptamer sgc8c immobilized at the AFM tip with its corresponding receptor, the protein tyrosine kinase-7 (PTK7) embedded in the membrane of acute lymphoblastic leukemia (ALL) cells (Jurkat T-cells). Performing single molecule force spectroscopy (SMFS) ex...

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Bibliographic Details
Published in:Anal Bioanal Chem
Main Authors: Leitner, Michael, Poturnayova, Alexandra, Lamprecht, Constanze, Weich, Sabine, Snejdarkova, Maja, Karpisova, Ivana, Hianik, Tibor, Ebner, Andreas
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2017
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Paper in Forefront
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366180/
https://ncbi.nlm.nih.gov/pubmed/28229174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-017-0238-5
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