Characterization of Enhanced Monovalent and Bivalent Thrombin DNA Aptamer Binding Using Single Molecule Force Spectroscopy

Thrombin aptamer binding strength and stability is dependent on sterical parameters when used for atomic force microscopy sensing applications. Sterical improvements on the linker chemistry were developed for high-affinity binding. For this we applied single molecule force spectroscopy using two enh...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Neundlinger, Isabel, Poturnayova, Alexandra, Karpisova, Ivana, Rankl, Christian, Hinterdorfer, Peter, Snejdarkova, Maja, Hianik, Tibor, Ebner, Andreas
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Biophysical Society 2011
Gaiak:
Spectroscopy, Imaging, and Other Techniques
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183820/
https://ncbi.nlm.nih.gov/pubmed/21961605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.07.054
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