Characterization of Enhanced Monovalent and Bivalent Thrombin DNA Aptamer Binding Using Single Molecule Force Spectroscopy

Thrombin aptamer binding strength and stability is dependent on sterical parameters when used for atomic force microscopy sensing applications. Sterical improvements on the linker chemistry were developed for high-affinity binding. For this we applied single molecule force spectroscopy using two enh...

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Bibliografski detalji
Glavni autori: Neundlinger, Isabel, Poturnayova, Alexandra, Karpisova, Ivana, Rankl, Christian, Hinterdorfer, Peter, Snejdarkova, Maja, Hianik, Tibor, Ebner, Andreas
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2011
Teme:
Spectroscopy, Imaging, and Other Techniques
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183820/
https://ncbi.nlm.nih.gov/pubmed/21961605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.07.054
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