Structure of nogalamycin bound to a DNA hexamer.

The anthracycline antibiotic nogalamycin, which binds to DNA, is composed of a planar aglycone substituted on each end to form an unusual dumbbell-shaped molecule. At one end nogalamycin contains an uncharged nogalose sugar and a methyl ester. At the other end nogalamycin contains a positively charg...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Williams, L D, Egli, M, Qi, G, Bash, P, van der Marel, G A, van Boom, J H, Rich, A, Frederick, C A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2315315/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.6.2225
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