Pharmacokinetics and Tissue Distribution of Benznidazole after Oral Administration in Mice

Specific chemotherapy using benznidazole (BNZ) for Chagas disease during the chronic stage is controversial due to its limited efficacy and toxic effects. Although BNZ has been used to treat Chagas disease since the 1970s, few studies about the biodistribution of this drug exist. In this study, BNZ...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Perin, Luísa, Moreira da Silva, Rodrigo, Fonseca, Kátia da Silva, Cardoso, Jamille Mirelle de Oliveira, Mathias, Fernando Augusto Siqueira, Reis, Levi Eduardo Soares, Molina, Israel, Correa-Oliveira, Rodrigo, Vieira, Paula Melo de Abreu, Carneiro, Cláudia Martins
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2017
Aiheet:
Pharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365712/
https://ncbi.nlm.nih.gov/pubmed/28167558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02410-16
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