Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays

In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mu...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ajileye, Adebisi, Alvarez, Nataly, Merker, Matthias, Walker, Timothy M., Akter, Suriya, Brown, Kerstin, Moradigaravand, Danesh, Schön, Thomas, Andres, Sönke, Schleusener, Viola, Omar, Shaheed V., Coll, Francesc, Huang, Hairong, Diel, Roland, Ismail, Nazir, Parkhill, Julian, de Jong, Bouke C., Peto, Tim E. A., Crook, Derrick W., Niemann, Stefan, Robledo, Jaime, Smith, E. Grace, Peacock, Sharon J., Köser, Claudio U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365657/
https://ncbi.nlm.nih.gov/pubmed/28137812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02169-16
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