Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling

BACKGROUND: Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder leading to ventricular arrhythmias and heart failure, mainly as a result of mutations in cardiac desmosomal genes. Desmosomes are cell-cell junctions mediating adhesion of cardiomyocytes; however, the molecular and cellu...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Brodehl, Andreas, Belke, Darrell D., Garnett, Lauren, Martens, Kristina, Abdelfatah, Nelly, Rodriguez, Marcela, Diao, Catherine, Chen, Yong-Xiang, Gordon, Paul M. K., Nygren, Anders, Gerull, Brenda
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365111/
https://ncbi.nlm.nih.gov/pubmed/28339476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174019
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