TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport

The up-regulation of thioredoxin reductase-1 (TrxR1) is detected in more than half of gliomas, which is significantly associated with increased malignancy grade and recurrence rate. The biological functions of NADPH-dependent TrxR1 are mainly associated with reduced thioredoxin-1 (Trx1) which plays...

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Vydáno v:Sci Rep
Hlavní autoři: Zhang, Yushuo, Chen, Fei, Tai, Guomei, Wang, Jiaojiao, Shang, Jun, Zhang, Bing, Wang, Ping, Huang, Baoxing, Du, Jie, Yu, Jiahua, Zhang, Haowen, Liu, Fenju
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364507/
https://ncbi.nlm.nih.gov/pubmed/28338004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42928
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