FMNL formins boost lamellipodial force generation

Migration frequently involves Rac-mediated protrusion of lamellipodia, formed by Arp2/3 complex-dependent branching thought to be crucial for force generation and stability of these networks. The formins FMNL2 and FMNL3 are Cdc42 effectors targeting to the lamellipodium tip and shown here to nucleat...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kage, Frieda, Winterhoff, Moritz, Dimchev, Vanessa, Mueller, Jan, Thalheim, Tobias, Freise, Anika, Brühmann, Stefan, Kollasser, Jana, Block, Jennifer, Dimchev, Georgi, Geyer, Matthias, Schnittler, Hans-Joachim, Brakebusch, Cord, Stradal, Theresia E. B., Carlier, Marie-France, Sixt, Michael, Käs, Josef, Faix, Jan, Rottner, Klemens
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364437/
https://ncbi.nlm.nih.gov/pubmed/28327544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14832
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