The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3

NKG2D is a major activating receptor of NK cells and plays a critical role in tumor immunosurveillance. NKG2D expression in NK cells is inhibited by the histone deacetylase (HDAC) inhibitor valproic acid (VPA) and enhanced by the narrow-spectrum HDAC inhibitor entinostat. We previously demonstrated...

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Publicado no:Sci Rep
Main Authors: Ni, Lulu, Wang, Lixin, Yao, Chao, Ni, Zhongya, Liu, Fei, Gong, Chenyuan, Zhu, Xiaowen, Yan, Xuewei, Watowich, Stephanie S., Lee, Dean A., Zhu, Shiguo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364405/
https://ncbi.nlm.nih.gov/pubmed/28338101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45266
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