Activity of the Pore-Forming Virulence Factor Listeriolysin O Is Reversibly Inhibited by Naturally Occurring S-Glutathionylation

Cholesterol-dependent cytolysins (CDCs) represent a family of homologous pore-forming proteins secreted by many Gram-positive bacterial pathogens. CDCs mediate membrane binding partly through a conserved C-terminal undecapeptide, which contains a single cysteine residue. While mutational changes to...

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Vydáno v:Infect Immun
Hlavní autoři: Portman, Jonathan L., Huang, Qiongying, Reniere, Michelle L., Iavarone, Anthony T., Portnoy, Daniel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Molecular Pathogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364301/
https://ncbi.nlm.nih.gov/pubmed/28138025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00959-16
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