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Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade

Cortical and hippocampal network hyperexcitability appears to be an early event in Alzheimer’s disease (AD) pathogenesis, and may contribute to memory impairment. It remains unclear if network hyperexcitability precedes memory impairment in mouse models of AD and what are the underlying cellular mec...

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Dettagli Bibliografici
Pubblicato in:Front Aging Neurosci
Autori principali: Kazim, Syed F., Chuang, Shih-Chieh, Zhao, Wangfa, Wong, Robert K. S., Bianchi, Riccardo, Iqbal, Khalid
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364175/
https://ncbi.nlm.nih.gov/pubmed/28392767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00071
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