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Prolonged withdrawal from cocaine self-administration affects prefrontal cortex- and basolateral amygdala-nucleus accumbens core circuits but not accumbens GABAergic local interneurons

Withdrawal from extended-access cocaine self-administration leads to progressive intensification (‘incubation’) of cocaine craving. After prolonged withdrawal (1–2 months), when craving is high, expression of incubation depends on strengthening of excitatory inputs to medium spiny neurons (MSN) of t...

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Bibliografische gegevens
Gepubliceerd in:Addict Biol
Hoofdauteurs: Purgianto, Anthony, Weinfeld, Michael E., Wolf, Marina E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364065/
https://ncbi.nlm.nih.gov/pubmed/27457780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12430
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