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Prolonged withdrawal from cocaine self-administration affects prefrontal cortex- and basolateral amygdala-nucleus accumbens core circuits but not accumbens GABAergic local interneurons

Withdrawal from extended-access cocaine self-administration leads to progressive intensification (‘incubation’) of cocaine craving. After prolonged withdrawal (1–2 months), when craving is high, expression of incubation depends on strengthening of excitatory inputs to medium spiny neurons (MSN) of t...

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Detalhes bibliográficos
Publicado no:Addict Biol
Main Authors: Purgianto, Anthony, Weinfeld, Michael E., Wolf, Marina E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364065/
https://ncbi.nlm.nih.gov/pubmed/27457780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12430
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