The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt

The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated via Notch’s interaction with the canonical Wnt pathway. Here, we propose a new mathematical model of the Notch and Wnt p...

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Publicat a:PLoS Comput Biol
Autors principals: Kay, Sophie K., Harrington, Heather A., Shepherd, Sarah, Brennan, Keith, Dale, Trevor, Osborne, James M., Gavaghan, David J., Byrne, Helen M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363986/
https://ncbi.nlm.nih.gov/pubmed/28245235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005400
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