Pre-clinical characterization of PKC412, a multi-kinase inhibitor, against colorectal cancer cells

The potential effect of PKC412, a small molecular multi-kinase inhibitor, in colorectal cancer (CRC) cells was evaluated here. We showed that PKC412 was cytotoxic and anti-proliferative against CRC cell lines (HT-29, HCT-116, HT-15 and DLD-1) and primary CRC cells. PKC412 provoked caspase-dependent...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Li, Jian-Ping, Huang, Zhi-Jun, Lu, Xing-Sheng, Zhou, Yi-Chan, Shao, Yun, He, Xiao-Pu, Chen, Su-Rong, Wang, Dong-Dong, Qin, Li-Sen, Sun, Wei-Hao
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363623/
https://ncbi.nlm.nih.gov/pubmed/27780925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12802
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