T-cell responses against CD19(+) pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blasts

T-cell immunotherapies are promising options in relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL). We investigated the effect of co-signaling molecules on T-cell attack against leukemia mediated by CD19/CD3-bispecific T-cell engager. Primary CD19(+) ALL blasts (n≥10) and physiologic...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Feucht, Judith, Kayser, Simone, Gorodezki, David, Hamieh, Mohamad, Döring, Michaela, Blaeschke, Franziska, Schlegel, Patrick, Bösmüller, Hans, Quintanilla-Fend, Leticia, Ebinger, Martin, Lang, Peter, Handgretinger, Rupert, Feuchtinger, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363558/
https://ncbi.nlm.nih.gov/pubmed/27708227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12357
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