Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells

Epstein-Barr virus (EBV) infects not only B cells, but also T cells and natural killer (NK) cells, and is associated with T or NK cell lymphoma. These lymphoid malignancies are refractory to conventional chemotherapy. We examined the activation of the JAK3/STAT5 pathway in EBV-positive and -negative...

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Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Ando, Shotaro, Kawada, Jun-ichi, Watanabe, Takahiro, Suzuki, Michio, Sato, Yoshitaka, Torii, Yuka, Asai, Masato, Goshima, Fumi, Murata, Takayuki, Shimizu, Norio, Ito, Yoshinori, Kimura, Hiroshi
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363550/
https://ncbi.nlm.nih.gov/pubmed/27732937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12529
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