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Lithium-induced neuroprotection in stroke involves increased miR-124 expression, reduced RE1-silencing transcription factor abundance and decreased protein deubiquitination by GSK3β inhibition-independent pathways

Lithium promotes acute poststroke neuronal survival, which includes mechanisms that are not limited to GSK3β inhibition. However, whether lithium induces long-term neuroprotection and enhanced brain remodeling is unclear. Therefore, mice were exposed to transient middle cerebral artery occlusion and...

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Dettagli Bibliografici
Pubblicato in:J Cereb Blood Flow Metab
Autori principali: Doeppner, Thorsten R, Kaltwasser, Britta, Sanchez-Mendoza, Eduardo H, Caglayan, Ahmet B, Bähr, Mathias, Hermann, Dirk M
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363471/
https://ncbi.nlm.nih.gov/pubmed/27126323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16647738
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