Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy

Current anti-epileptic drugs (AEDs) act on a limited set of neuronal targets, are ineffective in a third of patients with epilepsy, and do not show disease-modifying properties. MicroRNAs are small noncoding RNAs that regulate levels of proteins by post-transcriptional control of mRNA stability and...

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Publicado en:Mol Ther Nucleic Acids
Main Authors: Reschke, Cristina R., Silva, Luiz F. Almeida, Norwood, Braxton A., Senthilkumar, Ketharini, Morris, Gareth, Sanz-Rodriguez, Amaya, Conroy, Ronán M., Costard, Lara, Neubert, Valentin, Bauer, Sebastian, Farrell, Michael A., O’Brien, Donncha F., Delanty, Norman, Schorge, Stephanie, Pasterkamp, R. Jeroen, Rosenow, Felix, Henshall, David C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363384/
https://ncbi.nlm.nih.gov/pubmed/28325299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2016.11.002
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