Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics

It is not understood why healthy tissues can exhibit varying levels of sensitivity to the same toxic stimuli. Using BH3 Profiling, we find that mitochondria of many adult somatic tissues, including brain, heart and kidneys, are profoundly refractory to pro-apoptotic signaling, leading to cellular re...

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發表在:Cancer Cell
Main Authors: Sarosiek, Kristopher A., Fraser, Cameron, Muthalagu, Nathiya, Bhola, Patrick D., Chang, Weiting, McBrayer, Samuel K., Cantlon, Adam, Fisch, Sudeshna, Golomb-Mello, Gail, Ryan, Jeremy M., Deng, Jing, Jian, Brian, Corbett, Chris, Goldenberg, Marti, Madsen, Joseph R., Liao, Ronglih, Walsh, Dominic, Sedivy, John, Murphy, Daniel J., Carrasco, Daniel Ruben, Robinson, Shenandoah, Moslehi, Javid, Letai, Anthony
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363285/
https://ncbi.nlm.nih.gov/pubmed/28017613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.011
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