Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics

It is not understood why healthy tissues can exhibit varying levels of sensitivity to the same toxic stimuli. Using BH3 Profiling, we find that mitochondria of many adult somatic tissues, including brain, heart and kidneys, are profoundly refractory to pro-apoptotic signaling, leading to cellular re...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Cancer Cell
Главные авторы: Sarosiek, Kristopher A., Fraser, Cameron, Muthalagu, Nathiya, Bhola, Patrick D., Chang, Weiting, McBrayer, Samuel K., Cantlon, Adam, Fisch, Sudeshna, Golomb-Mello, Gail, Ryan, Jeremy M., Deng, Jing, Jian, Brian, Corbett, Chris, Goldenberg, Marti, Madsen, Joseph R., Liao, Ronglih, Walsh, Dominic, Sedivy, John, Murphy, Daniel J., Carrasco, Daniel Ruben, Robinson, Shenandoah, Moslehi, Javid, Letai, Anthony
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363285/
https://ncbi.nlm.nih.gov/pubmed/28017613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.011
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы