Llwytho...

Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics

It is not understood why healthy tissues can exhibit varying levels of sensitivity to the same toxic stimuli. Using BH3 Profiling, we find that mitochondria of many adult somatic tissues, including brain, heart and kidneys, are profoundly refractory to pro-apoptotic signaling, leading to cellular re...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Cell
Prif Awduron: Sarosiek, Kristopher A., Fraser, Cameron, Muthalagu, Nathiya, Bhola, Patrick D., Chang, Weiting, McBrayer, Samuel K., Cantlon, Adam, Fisch, Sudeshna, Golomb-Mello, Gail, Ryan, Jeremy M., Deng, Jing, Jian, Brian, Corbett, Chris, Goldenberg, Marti, Madsen, Joseph R., Liao, Ronglih, Walsh, Dominic, Sedivy, John, Murphy, Daniel J., Carrasco, Daniel Ruben, Robinson, Shenandoah, Moslehi, Javid, Letai, Anthony
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363285/
https://ncbi.nlm.nih.gov/pubmed/28017613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.011
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