Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics

It is not understood why healthy tissues can exhibit varying levels of sensitivity to the same toxic stimuli. Using BH3 Profiling, we find that mitochondria of many adult somatic tissues, including brain, heart and kidneys, are profoundly refractory to pro-apoptotic signaling, leading to cellular re...

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書誌詳細
出版年:Cancer Cell
主要な著者: Sarosiek, Kristopher A., Fraser, Cameron, Muthalagu, Nathiya, Bhola, Patrick D., Chang, Weiting, McBrayer, Samuel K., Cantlon, Adam, Fisch, Sudeshna, Golomb-Mello, Gail, Ryan, Jeremy M., Deng, Jing, Jian, Brian, Corbett, Chris, Goldenberg, Marti, Madsen, Joseph R., Liao, Ronglih, Walsh, Dominic, Sedivy, John, Murphy, Daniel J., Carrasco, Daniel Ruben, Robinson, Shenandoah, Moslehi, Javid, Letai, Anthony
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363285/
https://ncbi.nlm.nih.gov/pubmed/28017613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.011
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