Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia

Recently, an engineered Homeobox-nucleoporin fusion gene, NUP98-HOXA10HD or NA10HD, was reported to expand and maintain murine hematopoietic stem cells (HSCs). We postulated that NA10HD would increase the number of human γ-globin-expressing cells to therapeutic levels. We developed a double gene len...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Zhao, Hui Fen, Abraham, Allistair, Kim, Yoon-Sang, Wang, Yong-Dong, Pestina, Tamara, Zhan, Jun, Humphries, Keith, Nienhuis, Arthur W., Persons, Derek A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363206/
https://ncbi.nlm.nih.gov/pubmed/28190779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.01.019
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares