Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice

In vitro and ex vivo experiments indicate that elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, is an alternative pathway for angiotensin II (Ang II) generation. However, the role played by ELA-2 in vivo is unclear. We examined ELA-2 knockout (ELA-2KO) mice compared to w...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Becari, Christiane, Durand, Marina T., Guimaraes, Alessander O., Lataro, Renata M., Prado, Cibele M., de Oliveira, Mauro, Candido, Sarai C. O., Pais, Paloma, Ribeiro, Mauricio S., Bader, Michael, Pesquero, Joao B., Salgado, Maria C. O., Salgado, Helio C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363176/
https://ncbi.nlm.nih.gov/pubmed/28386233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00170
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