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Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2

The glutamine transporter ASCT2 has been identified as a promising target to inhibit rapid growth of cancer cells. However, ASCT2 pharmacology is not well established. In this report, we performed a systematic structure activity analysis of a series of substituted benzylproline derivatives. Substitu...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Singh, Kurnvir, Tanui, Rose, Gameiro, Armanda, Eisenberg, Gilad, Colas, Claire, Schlessinger, Avner, Grewer, Christof
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363072/
https://ncbi.nlm.nih.gov/pubmed/28057420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.12.063
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